Attention: Schizophrenia Risk Gene Product miR-137 Now Targeting EFNB2
نویسنده
چکیده
Article history: Received 4 October 2016 Accepted 4 October 2016 Available online 5 October 2016 to schizophrenia and does this variant have any effect on its function? Computationalmethods can identify the potential targets for a particular miRNA based on the seed sequence it uses to bind to usually the 3′UTR of the target mRNA (Oulas et al., 2015). To determine which targets are relevant to schizophrenia and worthy of further investigation, Wu et al. (2016) searched their previous study of theHan Chinese (Zhang et al.,
منابع مشابه
MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients
MicroRNAs (miRNAs) are a class of endogenous and non-coding single-stranded RNAs of approximately 22 nucleotides, many of which are evolutionarily conserved. Genome-wide association studies have identified a robust statistical association between the MIR137 gene and schizophrenia in Europeans, which was replicated in the Han Chinese population in a case-control study. In the previous study, we ...
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Single nucleotide polymorphisms (SNPs) within the MIR137 gene locus have been shown to confer risk for schizophrenia through genome-wide association studies (GWAS). The expression levels of microRNA-137 (miR-137) and its validated gene targets have also been shown to be disrupted in several neuropsychiatric conditions, including schizophrenia. Regulation of miR-137 expression is thus imperative...
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2016